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LONGEVITY with Nathalie Niddam

Jun 24, 2021

Biohackers often ask: How long do I need to fast before I am in autophagy?  The answers come back fast and furious and it appears that nobody can agree – 16 hours?  24 hours? 72 hours?  It turns out that the answer is frustratingly: “it depends”…it depends on you, your metabolic flexibility and more…the Biosense device is here to help individuals answer this burning question for themselves.

In this week’s episode Nathalie talks to Jim Howard from Readout Health about the Biosense Breath Ketone Monitoring device – a revolutionary method of measuring ketones more precisely without spilling a single drop of blood!  We talk about the ketones, fasting and a new feature on the Biosense App that will help users to tap into their body’s innate mechanisms of repair and renewal – cellular autophagy - by honing in on their individual response.


Meet This Week's Guest

Jim Howard is a 27-year medtech executive focused on value creation with novel approaches to patient care. Jim came to Readout as CEO from his EIR position at venture capital firm, BioGenerator, an initial investor in Readout.

He is a co-founder and initial CEO of Washington University spinout SentiAR, the first AR platform for interventional procedures, currently in clinical trials. Jim led a team of 50 as VP of Sales in CareFusion’s respiratory business unit through the acquisition by Becton Dickinson in 2016. He is a board director at POC medical device company, MagBiosense, and is an active mentor to new CEO’s in the St. Louis healthcare ecosystem.

Jim is passionate about behavioral changes in chronic diseases, putting the healthcare in the hands of patients. He has an MBA from University of Missouri-St.Louis and remains active in collaborations with Washington University researchers.


Episode Sponsor:

drinkHRW: This episode is sponsored by  manufacturers of the best molecular hydrogen supplements on the market.   For the past 4 years I have been using molecular hydrogen tablets every single day for dozens of reasons including mitigation of oxidative stress, to support my mitochondria and metabolic health, to help me recover from my workouts.  I am such a fan that I have every one of my clients using drinkHRW tablets as a foundation supplement in their stacks whether their goals are healthy aging or increased performance (or both).

Check out the amazing products at and use promo code Longevity10 to get 10% off your purchase!


Key Takeaways

[01:14] About Jim and how he got to run this cool company…

[05:13] The ketogenic diet, metabolic flexibility and IM fasting in the reversal of disease…

[09:32] What is being measured when using the Biosense?...

[12:20] Do the numbers on the Biosense mean the same thing for everyone?..

[15:17] Are continuous glucose monitors accurate?..

[17:52] The effect your microbiome has on your body’s response to sugar…

[21:21] Precision fasting, the direct way to get to autophagy…

[24:14] Redox potential, the ability of the body to store less BHB over time due to your body becoming more efficient…

[27:35] Precision Fast, an actual fasting wheel with precise actual levels of ketosis…

[28:59] How long does it take to get into ketosis, autophagy, ect? Is it the same time for everyone?..

[33:33] Tracking metabolic flexibility and ketone production with the Biosense in order to know your individual reactions to foods and exercise so that you can modify behaviors…

[36:26] The fast mimicking diet, is it good or bad?..

[45:47] What apps can you sync with Biosense?..


You can purchase the biosense at with promo code Longevity20 to save $20!




Instagram: @mybiosense



Disclaimer:  This podcast and the information presented are for informational purposes only and not intended to diagnose or treat disease.  Before making any changes to your nutrition or supplementation please check with your physician or health provider.