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Biohacking Superhuman Performance

Aug 17, 2021

My guest this week is Ryan Smith, VP of Business Development at TruDiagnostic.

In this episode, Ryan and I discuss how TruDiagnostic got started, the services they offer and more!


Learn more about TruDiagnostic at Use promocode longevity12 for 12% off.


Ryan Smith attended Transylvania University and graduated with a degree in Biochemistry. After finishing all the educational curriculum and passing USMLE Step 1 he decided to leave and open up a pharmacy in the United States that focused on peptide synthesis and formulations for pharmaceutical preparations. That pharmacy, Tailor Made Compounding, became the 4th fastest growing company in healthcare in the US. Ryan exited Tailor Made in late 2020. Since then, Ryan has opened many businesses including TruDiagnostic, a company focusing on methylation array-based diagnostics for life extension and preventive healthcare. TruDiagnostic is a CLIA certified lab and health data company focused on serving integrative and functional medicine providers in the United States. TruDiagnostic has a commitment to research with over 21 approved clinical research studies investigating the epigenetic methylation changes of a variety of longevity and health interventions. Since Tru Diagnostics inception, they have created one of the largest private epigenetic health databases in the world with over 13,000 patients tested.


Follow Ryan Smith at TruDiagnostic

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Episode Takeaways

[07:30] How long have we been able to do epigenetic methylation testing for the average consumer?..

[08:40] What brought Ryan to where he is today?..

[13:47] What is epigenetics? 

[16:15] What is the difference between the TruDiagnostic test and MTHFR genetic testing?

[19:35] Establishing biological age vs chronological age...

[23:26] The link between methylation and age..

[28:20] Dunedin Study..

[33:50] Is there anything you can do to slow the rate of aging or is it predetermined?..

[39:29] The impact of stress and cortisol on aging. Is DHEA the key to anti-aging?..

[41:35] Is higher growth hormone and higher IGF1 detrimental to aging or anti-aging?

[46:40] The effect of a mothers stress on her fetus. How much of aging is genetic?..

[49:47] What are the different reports that TruDiagnostic offers?

[55:00] Studies on the effect of COVID and the COVID vaccine on epigenetics..

[58:00] Smoking and drinking, how they affect epigenetics..

[64:00] Creating personalized plans based on epigenetics..

[68:53] Are there ways to reverse epigenetic aging caused by bad habits such as smoking?..

[72:02] Is TruDiagnostic tracking the effect of bioregulator peptides and other supplements on genes?..

[77:15] How does TruDiagnostic run their tests and how do they know if you are doing a good epigenetic test?..

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Disclaimer:  This podcast and the information presented are for informational purposes only and not intended to diagnose or treat disease.  Before making any changes to your nutrition or supplementation please check with your physician or health provider.